治疗犬淋巴癌药，Vincristine, L-久久健康网

治疗犬淋巴癌药，Vincristine, L

发布时间： 2009-11-27 12:13:13 来源：www.mypethome.com

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什么是自体免疫性肝炎

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犬淋巴癌的治疗：

TREATMENTCombinationchemotherapyforlymphoma主要就是依靠化疗,whichisatreatmentregimenwherethedogisadministeredtwoormoredrugsonaparticularschedule,isthestandardtherapy.Clinically,themosteffectivetreatmentregimen,calledUW-M,hasresultedinresponserates（tumorregression）ashighas91%forperiodsof6monthsormore.Thisregimenusesacombinationof5drugs结合这5种药（Vincristine,L-Asparaginase,Prednisone,CyclophosphomideandDoxorubicin）,administeredoveranineweekperiod.Ifthisinitialtreatmentscheduleissuccessfulinproducingremissionofthedisease,thenthistreatmentisfollowedbyamaintenancedrugschedule,whichideallycontinuesforupto2years.Single-agenttherapywithDoxorubicinaloneorPrednisonealonealsoproducesremissions,albeitwithshorterdurations,insomedogsandprovidesamoreconvenienttreatmentscheduleforpetowners.Immunotherapywithamonoclonalantibody（Mab231）thatspecificallyrecognizessomecaninelymphomashasbeenusedsuccessfullyfollowingchemotherapyforthepurposeofprolongingdiseaseremission.Conventionalradiationtherapyhasbeenfoundtobeineffectiveagainstlymphoma.However,clinicalstudiesexploringradiationtherapywithbone-marrowtransplantindogsindicatesapossibletherapeuticgainmaybeachievedbycombiningthesetwomethods.
PROGNOSIS:Withouttherapy,dogsdiagnosedwithlymphomasuccumbtothediseasewithin4-6weeksfollowingdiagnosis.ThereisstrongevidencetosuggestthatlymphomasdevelopedfromT-lymphocytesaremoreaggressiveandbearapoorerprognosisthanthosedevelopedfromB-lymphocytes.Treatmentproducestumorremissioninapproximately90%ofcases,withdurationofremissionandsurvivaldependentuponthetreatmentregimenused.UseofPrednisonealonehelpstoimprovequalityoflife,however,remissionsarebrief,lastingonlyabout30days.CombiningCyclophosphamidewithPrednisonemayprovideaslightlylongerdurationofremission（30-60days）.TreatmentwithDoxorubinalonehasproducedremissionsforupto18-29weeks.Arecentstudyindicatesthatmonitoringplasmaglutathione-S-transferasemaybehelpfulinevaluatingtherapeuticresponsetodoxorubicintreatment.TheUW-Mprotocol（describedabove）hasdemonstratedthelongestdurationsofremissionslasting44-69weeksforearlystagelymphomasand36-51weeksformoreadvancedlymphomas.

PREVENTION:Considerableevidencelinksdevelopmentoflymphomawithdefectsinorsuppressionoftheimmunesystem.Therefore,preventionoflymphomamaylieineffortstoprotectpredisposeddogswithimmunodeficiencyorauto-immunediseasesfromexposuretoenvironmentalcarcinogensthatincreaselikelihoodofcancerdevelopment.Additionally,frequentuseofimmunosuppressivedrugsmayalsoincreaseriskoflymphoma.

[[i]本帖最后由stephen123777于2007-9-2012:45编辑[/i]]

治疗犬淋巴癌药，Vincristine, L

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什么是自体免疫性肝炎

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